Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia

Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) that impair its expression and/or chloride channel function. Here, we provide evidence that type 4 cyclic nucleotide phosphodiesterases (PDE4s) are critical regulators of t...

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Bibliografiske detaljer
Main Authors: Blanchard, Elise, Zlock, Lorna, Lao, Anna, Mika, Delphine, Namkung, Wan, Xie, Moses, Scheitrum, Colleen, Gruenert, Dieter C., Verkman, Alan S., Finkbeiner, Walter E., Conti, Marco, Richter, Wito
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2014
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898646/
https://ncbi.nlm.nih.gov/pubmed/24200884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-240861
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