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β(1)-adrenergic receptor antagonists signal via PDE4 translocation
It is generally assumed that antagonists of G(s)-coupled receptors do not activate cAMP signalling, because they do not stimulate cAMP production via G(s)-protein/adenylyl cyclase activation. Here, we report a new signalling pathway whereby antagonists of β(1)-adrenergic receptors (β(1)ARs) increase...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
European Molecular Biology Organization
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3589095/ https://ncbi.nlm.nih.gov/pubmed/23381222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.4 |
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