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PDE4B mediates local feedback regulation of β(1)-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes
Multiple cAMP phosphodiesterase (PDE) isoforms play divergent roles in cardiac homeostasis but the molecular basis for their non-redundant function remains poorly understood. Here, we report a novel role for the PDE4B isoform in β-adrenergic (βAR) signaling in the heart. Genetic ablation of PDE4B di...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3937773/ https://ncbi.nlm.nih.gov/pubmed/24413164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.140251 |
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