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Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on β-adrenergic cAMP signals

RATIONALE: Multiple cyclic nucleotide phosphodiesterases (PDEs) degrade cAMP in cardiomyocytes but the role of PDEs in controlling cAMP signaling during pathological cardiac hypertrophy (CH) is poorly defined. OBJECTIVE: Evaluate the β-adrenergic regulation of cardiac contractility and characterize...

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Autori principali: Abi-Gerges, Aniella, Richter, Wito, Lefebvre, Florence, Mateo, Philippe, Varin, Audrey, Heymes, Christophe, Samuel, Jane-Lise, Lugnier, Claire, Conti, Marco, Fischmeister, Rodolphe, Vandecasteele, Grégoire
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2792993/
https://ncbi.nlm.nih.gov/pubmed/19745166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.197947
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