β-Adrenergic cAMP Signals Are Predominantly Regulated by Phosphodiesterase Type 4 in Cultured Adult Rat Aortic Smooth Muscle Cells

BACKGROUND: We investigated the role of cyclic nucleotide phosphodiesterases (PDEs) in the spatiotemporal control of intracellular cAMP concentrations in rat aortic smooth muscle cells (RASMCs). METHODOLOGY/PRINCIPAL FINDINGS: The rank order of PDE families contributing to global cAMP-PDE activity w...

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Detalhes bibliográficos
Main Authors: Zhai, Kui, Hubert, Fabien, Nicolas, Valérie, Ji, Guangju, Fischmeister, Rodolphe, Leblais, Véronique
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475707/
https://ncbi.nlm.nih.gov/pubmed/23094097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047826
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