Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following β(2)-adrenergic stimulation of I(Ca,L) in frog ventricular myocytes

The role of cyclic nucleotide phosphodiesterase (PDE) isoforms in the β(2)-adrenergic stimulation of the L-type Ca(2+) current (I(Ca,L)) was investigated in frog ventricular myocytes using double patch-clamp and double-barrelled microperfusion techniques. Isoprenaline (ISO, 1 nM to 10 μM) was applie...

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Detalhes bibliográficos
Main Authors: Jurevičius, Jonas, Skeberdis, V Arvydas, Fischmeister, Rodolphe
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2003
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2343164/
https://ncbi.nlm.nih.gov/pubmed/12815180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.045211
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