A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes

Compartmentation of cAMP is thought to generate the specificity of G(s)-coupled receptors action in cardiac myocytes, with phosphodiesterases (PDEs) playing a major role in this process by preventing cAMP diffusion. We have tested this hypothesis in adult rat ventricular myocytes (ARVMs) by characte...

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Detalhes bibliográficos
Main Authors: Rochais, Francesca, Abi-Gerges, Aniella, Horner, Kathleen, Lefebvre, Florence, Cooper, Dermot M.F, Conti, Marco, Fischmeister, Rodolphe, Vandecasteele, Grégoire
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099453/
https://ncbi.nlm.nih.gov/pubmed/16556871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/01.RES.0000218493.09370.8e
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