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Whole chromosome instability resulting from the synergistic effects of pRB and p53 inactivation
Whole chromosome instability (CIN) is a common feature of cancer cells and has been linked to increased tumor evolution and metastasis. Several studies have shown that the loss of the pRB tumor suppressor causes mitotic defects and chromosome missegregation. pRB is inactivated in many types of cance...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3884049/ https://ncbi.nlm.nih.gov/pubmed/23792446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.201 |
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