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Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion
Chromosome instability (CIN), a common feature of solid tumors, promotes tumor evolution and increases drug resistance during therapy. We previously demonstrated that loss of the pRB tumor suppressor causes changes in centromere structure and generates CIN. However, the reason for, and significance...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4047977/ https://ncbi.nlm.nih.gov/pubmed/24613344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.01.032 |
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