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Loss of pRB causes centromere dysfunction and chromosomal instability
Chromosome instability (CIN) is a common feature of tumor cells. By monitoring chromosome segregation, we show that depletion of the retinoblastoma protein (pRB) causes rates of missegregation comparable with those seen in CIN tumor cells. The retinoblastoma tumor suppressor is frequently inactivate...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2895196/ https://ncbi.nlm.nih.gov/pubmed/20551165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1917310 |
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