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Loss of pRB causes centromere dysfunction and chromosomal instability

Chromosome instability (CIN) is a common feature of tumor cells. By monitoring chromosome segregation, we show that depletion of the retinoblastoma protein (pRB) causes rates of missegregation comparable with those seen in CIN tumor cells. The retinoblastoma tumor suppressor is frequently inactivate...

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書目詳細資料
Main Authors: Manning, Amity L., Longworth, Michelle S., Dyson, Nicholas J.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895196/
https://ncbi.nlm.nih.gov/pubmed/20551165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1917310
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