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Whole chromosome instability resulting from the synergistic effects of pRB and p53 inactivation

Whole chromosome instability (CIN) is a common feature of cancer cells and has been linked to increased tumor evolution and metastasis. Several studies have shown that the loss of the pRB tumor suppressor causes mitotic defects and chromosome missegregation. pRB is inactivated in many types of cance...

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Detalhes bibliográficos
Main Authors: Manning, Amity L., Benes, Cyril, Dyson, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3884049/
https://ncbi.nlm.nih.gov/pubmed/23792446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.201
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