Free energy profiles of base flipping in intercalative polycyclic aromatic hydrocarbon-damaged DNA duplexes: Energetic and structural relationships to nucleotide excision repair susceptibility

[Image: see text] The crystal structure of Rad4/Rad23, the yeast homolog of the human nucleotide excision repair (NER) lesion recognition factor XPC-RAD23B (Min and Pavletich, (2007) Nature 449:570–575) reveals that the lesion-partner base is flipped out of the helix and binds the protein. This sugg...

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Hauptverfasser: Cai, Yuqin, Zheng, Han, Ding, Shuang, Kropachev, Konstantin, Schwaid, Adam G., Tang, Yijin, Mu, Hong, Wang, Shenglong, Geacintov, Nicholas E., Zhang, Yingkai, Broyde, Suse
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865170/
https://ncbi.nlm.nih.gov/pubmed/23758590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400156a
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