The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor

The function of G protein-coupled receptors (GPCRs) can be modulated by a number of endogenous allosteric molecules. In this study, we used molecular dynamics, radioligand binding and thermostability experiments to elucidate the role of the recently discovered sodium ion binding site in the alloster...

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Huvudupphovsmän: Gutiérrez-de-Terán, Hugo, Massink, Arnault, Rodríguez, David, Liu, Wei, Han, Gye Won, Joseph, Jeremiah S., Katritch, Ilia, Heitman, Laura H., Xia, Lizi, IJzerman, Adriaan P., Cherezov, Vadim, Katritch, Vsevolod, Stevens, Raymond C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858454/
https://ncbi.nlm.nih.gov/pubmed/24210756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.09.020
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