Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

In the current studies we generated transgenic mice that overexpress human Insig-1 in the liver under a constitutive promoter. In cultured cells Insig-1 and Insig-2 have been shown to block lipid synthesis in a cholesterol-dependent fashion by inhibiting proteolytic processing of sterol regulatory e...

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Vydáno v:J Clin Invest
Hlavní autoři: Engelking, Luke J., Kuriyama, Hiroshi, Hammer, Robert E., Horton, Jay D., Brown, Michael S., Goldstein, Joseph L., Liang, Guosheng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2004
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Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC385408/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15085196/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI20978
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