Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin

Insig-1 and Insig-2 are regulatory proteins that restrict the cholesterol biosynthetic pathway by preventing proteolytic activation of SREBPs and by enhancing degradation of HMG-CoA reductase. Here, we created Insig–double-knockout (Insig-DKO) mice that are homozygous for null mutations in Insig-1 a...

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Main Authors: Engelking, Luke J., Evers, Bret M., Richardson, James A., Goldstein, Joseph L., Brown, Michael S., Liang, Guosheng
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2006
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1555642/
https://ncbi.nlm.nih.gov/pubmed/16955138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28988
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