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Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin
Insig-1 and Insig-2 are regulatory proteins that restrict the cholesterol biosynthetic pathway by preventing proteolytic activation of SREBPs and by enhancing degradation of HMG-CoA reductase. Here, we created Insig–double-knockout (Insig-DKO) mice that are homozygous for null mutations in Insig-1 a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1555642/ https://ncbi.nlm.nih.gov/pubmed/16955138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28988 |
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