Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin

Insig-1 and Insig-2, two closely related proteins, are essential for feedback inhibition of cholesterol biosynthesis. Here, we characterized a line of epidermal-specific, Insig-double knockout (Epi-Insig-DKO) mice lacking both Insigs in epidermis. At birth, Epi-Insig-DKO mice were indistinguishable...

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Hauptverfasser: Evers, Bret M., Farooqi, Midhat S., Shelton, John M., Richardson, James A., Goldstein, Joseph L., Brown, Michael S., Liang, Guosheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929004/
https://ncbi.nlm.nih.gov/pubmed/20090767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2009.442
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