Schoenheimer effect explained – feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

End-product feedback inhibition of cholesterol synthesis was first demonstrated in living animals by Schoenheimer 72 years ago. Current studies define Insig proteins as essential elements of this feedback system in mouse liver. In cultured cells, Insig proteins are required for sterol-mediated inhib...

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Autori principali: Engelking, Luke J., Liang, Guosheng, Hammer, Robert E., Takaishi, Kiyosumi, Kuriyama, Hiroshi, Evers, Bret M., Li, Wei-Ping, Horton, Jay D., Goldstein, Joseph L., Brown, Michael S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2005
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1184040/
https://ncbi.nlm.nih.gov/pubmed/16100574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25614
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