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Schoenheimer effect explained – feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
End-product feedback inhibition of cholesterol synthesis was first demonstrated in living animals by Schoenheimer 72 years ago. Current studies define Insig proteins as essential elements of this feedback system in mouse liver. In cultured cells, Insig proteins are required for sterol-mediated inhib...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1184040/ https://ncbi.nlm.nih.gov/pubmed/16100574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25614 |
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