Schoenheimer effect explained – feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

End-product feedback inhibition of cholesterol synthesis was first demonstrated in living animals by Schoenheimer 72 years ago. Current studies define Insig proteins as essential elements of this feedback system in mouse liver. In cultured cells, Insig proteins are required for sterol-mediated inhib...

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Detalhes bibliográficos
Main Authors: Engelking, Luke J., Liang, Guosheng, Hammer, Robert E., Takaishi, Kiyosumi, Kuriyama, Hiroshi, Evers, Bret M., Li, Wei-Ping, Horton, Jay D., Goldstein, Joseph L., Brown, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1184040/
https://ncbi.nlm.nih.gov/pubmed/16100574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25614
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