A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

Por Brown, Michael S., Goldstein, Joseph L.
Publicado em 1999

Familial Hypercholesterolemia: Defective Binding of Lipoproteins to Cultured Fibroblasts Associated with Impaired Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Acti...

Por Brown, Michael S., Goldstein, Joseph L.
Publicado em 1974

Familial Hypercholesterolemia: Identification of a Defect in the Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity Associated with Overproduction of Cholestero...

Por Goldstein, Joseph L., Brown, Michael S.
Publicado em 1973

From fatty streak to fatty liver: 33 years of joint publications in the JCI

Por Goldstein, Joseph L., Brown, Michael S.
Publicado em 2008

Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL

Por Brown, Michael S., Goldstein, Joseph L.
Publicado em 2009

History of Discovery: The LDL Receptor

Por Goldstein, Joseph L., Brown, Michael S.
Publicado em 2009

Richard G.W. Anderson (1940–2011) and the birth of receptor-mediated endocytosis

Por Brown, Michael S., Goldstein, Joseph L.
Publicado em 2011

Scientific Side Trips: Six Excursions from the Beaten Path

Por Brown, Michael S., Goldstein, Joseph L.
Publicado em 2012

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

Por Goldstein, Joseph L., Brown, Michael S.
Publicado no Cell (2015)

Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization

Por Goldstein, Joseph L., Wilson, Jean D.
Publicado em 1972

Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1

Por Scheek, Sigrid, Brown, Michael S., Goldstein, Joseph L.
Publicado em 1997

Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N

Por Nohturfft, Axel, Brown, Michael S., Goldstein, Joseph L.
Publicado em 1998

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

Por Yabe, Daisuke, Brown, Michael S., Goldstein, Joseph L.
Publicado em 2002

Receptor-mediated uptake of low density lipoprotein reconstituted with 25-hydroxycholesteryl oleate suppresses 3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growth o...

Por Krieger, Monty, Goldstein, Joseph L., Brown, Michael S.
Publicado em 1978

Feedback Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase

Por Kita, Toru, Brown, Michael S., Goldstein, Joseph L.
Publicado em 1980

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

Por Li, Shijie, Brown, Michael S., Goldstein, Joseph L.
Publicado em 2010

HDL miR-ed Down by SREBP Introns

Por Brown, Michael S., Ye, Jin, Goldstein, Joseph L.
Publicado em 2010

Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex

Por Tian, Jing, Goldstein, Joseph L., Brown, Michael S.
Publicado no Proc Natl Acad Sci U S A (2016)

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Por Horton, Jay D., Goldstein, Joseph L., Brown, Michael S.
Publicado em 2002

Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles

Por Adams, Christopher M., Goldstein, Joseph L., Brown, Michael S.
Publicado em 2003