Familial Hypercholesterolemia: Defective Binding of Lipoproteins to Cultured Fibroblasts Associated with Impaired Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity

Monolayers of cultured fibroblasts from normal human subjects bind (125)I-labeled low-density lipoproteins with high affinity and specificity. High affinity binding of similar magnitude was not observed in cells from five unrelated subjects with the homozygous form of familial hypercholesterolemia....

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Bibliographic Details
Main Authors: Brown, Michael S., Goldstein, Joseph L.
Format: Artigo
Language:Inglês
Published: 1974
Subjects:
Biological Sciences: Medical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC388099/
https://ncbi.nlm.nih.gov/pubmed/4362634
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