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Familial Hypercholesterolemia: Defective Binding of Lipoproteins to Cultured Fibroblasts Associated with Impaired Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity

Monolayers of cultured fibroblasts from normal human subjects bind (125)I-labeled low-density lipoproteins with high affinity and specificity. High affinity binding of similar magnitude was not observed in cells from five unrelated subjects with the homozygous form of familial hypercholesterolemia....

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Detalhes bibliográficos
Principais autores: Brown, Michael S., Goldstein, Joseph L.
Formato: Artigo
Idioma:Inglês
Publicado em: 1974
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC388099/
https://ncbi.nlm.nih.gov/pubmed/4362634
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