Familial Hypercholesterolemia: Defective Binding of Lipoproteins to Cultured Fibroblasts Associated with Impaired Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity

Monolayers of cultured fibroblasts from normal human subjects bind (125)I-labeled low-density lipoproteins with high affinity and specificity. High affinity binding of similar magnitude was not observed in cells from five unrelated subjects with the homozygous form of familial hypercholesterolemia....

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Brown, Michael S., Goldstein, Joseph L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1974
Assuntos:	Biological Sciences: Medical Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC388099/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4362634/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.3.788
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