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Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig

Cholesterol synthesis in animals is controlled by the regulated transport of sterol regulatory element-binding proteins (SREBPs) from the endoplasmic reticulum to the Golgi, where the transcription factors are processed proteolytically to release active fragments. Transport is inhibited by either ch...

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Main Authors: Radhakrishnan, Arun, Ikeda, Yukio, Kwon, Hyock Joo, Brown, Michael S., Goldstein, Joseph L.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851665/
https://ncbi.nlm.nih.gov/pubmed/17428920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700899104
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