Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

Insulin activates sterol regulatory element-binding protein-1c (SREBP-1c) in liver, thereby increasing fatty acid and triglyceride synthesis. We created a line of transgenic rats that produce epitope-tagged human SREBP-1c in liver under control of the constitutive apolipoprotein E promoter/enhancer....

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Autors principals: Owen, Joshua L., Zhang, Yuanyuan, Bae, Soo-Han, Farooqi, Midhat S., Liang, Guosheng, Hammer, Robert E., Goldstein, Joseph L., Brown, Michael S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479583/
https://ncbi.nlm.nih.gov/pubmed/22927400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213343109
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