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Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver

Transcription of the gene encoding sterol regulatory element-binding protein 1c (SREBP-1c) is known to be activated by insulin in the liver. The resultant SREBP-1c protein activates transcription of the genes required for fatty acid synthesis. Here, we use SREBP-1c promoter reporter constructs to di...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Chen, Guoxun, Liang, Guosheng, Ou, Jiafu, Goldstein, Joseph L., Brown, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC509189/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15266058/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0404297101
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