The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals

Insulin resistance leads to hypertriglyceridemia and hepatic steatosis and is associated with increased SREBP-1c, a transcription factor that activates fatty acid synthesis. Here, we show that steatosis in insulin-resistant ob/ob mice was abolished by deletion of Scap, an escort protein necessary fo...

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Главные авторы: Moon, Young-Ah, Liang, Guosheng, Xie, Xuefen, Frank-Kamenetsky, Maria, Fitzgerald, Kevin, Koteliansky, Victor, Brown, Michael S., Goldstein, Joseph L., Horton, Jay D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662050/
https://ncbi.nlm.nih.gov/pubmed/22326225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.12.017
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