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Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

Elongation of very long chain fatty acids (ELOVL)5 is one of seven mammalian fatty acid condensing enzymes involved in microsomal fatty acid elongation. To determine the in vivo substrates and function of ELOVL5, we generated Elovl5(−/−) mice. Studies using liver microsomal protein from wild-type an...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Moon, Young-Ah, Hammer, Robert E., Horton, Jay D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638104/
https://ncbi.nlm.nih.gov/pubmed/18838740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800383-JLR200
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