Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

The synthesis of cholesterol and fatty acids (FA) in the liver is independently regulated by SREBP-2 and SREBP-1c, respectively. Here, we genetically deleted Srebf-2 from hepatocytes and confirmed that SREBP-2 regulates all genes involved in cholesterol biosynthesis, the LDL receptor, and PCSK9; a s...

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Udgivet i:eLife
Main Authors: Rong, Shunxing, Cortés, Víctor A, Rashid, Shirya, Anderson, Norma N, McDonald, Jeffrey G, Liang, Guosheng, Moon, Young-Ah, Hammer, Robert E, Horton, Jay D
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Human Biology and Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348127/
https://ncbi.nlm.nih.gov/pubmed/28244871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25015
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