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Cholesterol auxotrophy and intolerance to ezetimibe in mice with SREBP-2 deficiency in the intestine
SREBP-2 activates transcription of all genes needed for cholesterol biosynthesis. To study SREBP-2 function in the intestine, we generated a mouse model (Vil-BP2(−/−)) in which Cre recombinase ablates SREBP-2 in intestinal epithelia. Intestines of Vil-BP2(−/−) mice had reduced expression of genes re...
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| Udgivet i: | J Lipid Res |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Biochemistry and Molecular Biology
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5625122/ https://ncbi.nlm.nih.gov/pubmed/28630260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M077610 |
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