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Cholesterol auxotrophy and intolerance to ezetimibe in mice with SREBP-2 deficiency in the intestine

SREBP-2 activates transcription of all genes needed for cholesterol biosynthesis. To study SREBP-2 function in the intestine, we generated a mouse model (Vil-BP2(−/−)) in which Cre recombinase ablates SREBP-2 in intestinal epithelia. Intestines of Vil-BP2(−/−) mice had reduced expression of genes re...

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Detalles Bibliográficos
Publicado en:J Lipid Res
Main Authors: Rong, Shunxing, McDonald, Jeffrey G., Engelking, Luke J.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625122/
https://ncbi.nlm.nih.gov/pubmed/28630260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M077610
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