Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR

Sterol regulatory element-binding protein-1c (SREBP-1c) enhances transcription of genes encoding enzymes of unsaturated fatty acid biosynthesis in liver. SREBP-1c mRNA is known to increase when cells are treated with agonists of liver X receptor (LXR), a nuclear hormone receptor, and to decrease whe...

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Главные авторы: Ou, Jiafu, Tu, Hua, Shan, Bei, Luk, Alvin, DeBose-Boyd, Russell A., Bashmakov, Yuriy, Goldstein, Joseph L., Brown, Michael S.
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 2001
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC33416/
https://ncbi.nlm.nih.gov/pubmed/11371634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.111138698
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