Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR

Sterol regulatory element-binding protein-1c (SREBP-1c) enhances transcription of genes encoding enzymes of unsaturated fatty acid biosynthesis in liver. SREBP-1c mRNA is known to increase when cells are treated with agonists of liver X receptor (LXR), a nuclear hormone receptor, and to decrease whe...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Ou, Jiafu, Tu, Hua, Shan, Bei, Luk, Alvin, DeBose-Boyd, Russell A., Bashmakov, Yuriy, Goldstein, Joseph L., Brown, Michael S.
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 2001
主題:	Biological Sciences
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11371634/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.111138698
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