Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

The NH2-terminal domain of sterol-regulatory element binding protein-1a (SREBP-1a) activates transcription of genes encoding enzymes of cholesterol and fatty acid biosynthesis in cultured cells. This domain is synthesized as part of a membrane-bound precursor that is attached to the nuclear envelope...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Shimano, H, Horton, J D, Hammer, R E, Shimomura, I, Brown, M S, Goldstein, J L
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507590/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8833906/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118951
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