Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

Feedback regulation of cholesterol biosynthesis is mediated by membrane-bound transcription factors designated sterol regulatory element-binding proteins (SREBP)-1 and -2. In sterol-deprived cultured cells, SREBPs are released from membranes by a proteolytic process that is stimulated by SREBP cleav...

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Detalhes bibliográficos
Main Authors: Korn, B S, Shimomura, I, Bashmakov, Y, Hammer, R E, Horton, J D, Goldstein, J L, Brown, M S
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC509159/
https://ncbi.nlm.nih.gov/pubmed/9854040
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