SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

In liver, the synthesis of cholesterol and fatty acids increases in response to cholesterol deprivation and insulin elevation, respectively. This regulatory mechanism underlies the adaptation to cholesterol synthesis inhibitors (statins) and high calorie diets (insulin). In nonhepatic cells, lipid s...

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Detaylı Bibliyografya
Yayımlandı:Genes Dev
Asıl Yazarlar: Matsuda, Morihiro, Korn, Bobby S., Hammer, Robert E., Moon, Young-Ah, Komuro, Ryutaro, Horton, Jay D., Goldstein, Joseph L., Brown, Michael S., Shimomura, Iichiro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2001
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313801/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11358865/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.891301
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