SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

In liver, the synthesis of cholesterol and fatty acids increases in response to cholesterol deprivation and insulin elevation, respectively. This regulatory mechanism underlies the adaptation to cholesterol synthesis inhibitors (statins) and high calorie diets (insulin). In nonhepatic cells, lipid s...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Matsuda, Morihiro, Korn, Bobby S., Hammer, Robert E., Moon, Young-Ah, Komuro, Ryutaro, Horton, Jay D., Goldstein, Joseph L., Brown, Michael S., Shimomura, Iichiro
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2001
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC313801/
https://ncbi.nlm.nih.gov/pubmed/11358865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.891301
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki