SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

In liver, the synthesis of cholesterol and fatty acids increases in response to cholesterol deprivation and insulin elevation, respectively. This regulatory mechanism underlies the adaptation to cholesterol synthesis inhibitors (statins) and high calorie diets (insulin). In nonhepatic cells, lipid s...

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Main Authors: Matsuda, Morihiro, Korn, Bobby S., Hammer, Robert E., Moon, Young-Ah, Komuro, Ryutaro, Horton, Jay D., Goldstein, Joseph L., Brown, Michael S., Shimomura, Iichiro
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2001
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC313801/
https://ncbi.nlm.nih.gov/pubmed/11358865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.891301
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