SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

In liver, the synthesis of cholesterol and fatty acids increases in response to cholesterol deprivation and insulin elevation, respectively. This regulatory mechanism underlies the adaptation to cholesterol synthesis inhibitors (statins) and high calorie diets (insulin). In nonhepatic cells, lipid s...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Matsuda, Morihiro, Korn, Bobby S., Hammer, Robert E., Moon, Young-Ah, Komuro, Ryutaro, Horton, Jay D., Goldstein, Joseph L., Brown, Michael S., Shimomura, Iichiro
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Cold Spring Harbor Laboratory Press 2001
Θέματα:
Research Paper
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC313801/
https://ncbi.nlm.nih.gov/pubmed/11358865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.891301
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