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Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis

Insig-1 and -2 are closely related proteins of the endoplasmic reticulum (ER) that block proteolytic activation of sterol regulatory element-binding proteins (SREBPs), transcription factors that activate the synthesis of cholesterol and fatty acids in liver and other organs. When cellular cholestero...

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Detalhes bibliográficos
Main Authors: Yabe, Daisuke, Komuro, Ryutaro, Liang, Guosheng, Goldstein, Joseph L., Brown, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152262/
https://ncbi.nlm.nih.gov/pubmed/12624180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0130116100
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