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Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

Overexpression of the nuclear form of sterol regulatory element-binding protein-1c (nSREBP-1c/ADD1) in cultured 3T3-L1 preadipocytes was shown previously to promote adipocyte differentiation. Here, we produced transgenic mice that overexpress nSREBP-1c in adipose tissue under the control of the adip...

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Bibliografiske detaljer
Main Authors: Shimomura, Iichiro, Hammer, Robert E., Richardson, James A., Ikemoto, Shinji, Bashmakov, Yuriy, Goldstein, Joseph L., Brown, Michael S.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1998
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC317215/
https://ncbi.nlm.nih.gov/pubmed/9784493
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