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Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

Sterol regulatory element binding proteins (SREBPs) enhance transcription of genes encoding enzymes of cholesterol and fatty acid biosynthesis and uptake. In the current experiments, we observed a decline in the mRNA encoding one SREBP isoform, SREBP-1c, in the livers of rats that were rendered diab...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Shimomura, Iichiro, Bashmakov, Yuriy, Ikemoto, Shinji, Horton, Jay D., Brown, Michael S., Goldstein, Joseph L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24120/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10570128/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.24.13656
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