Safety, pharmacokinetics and pharmacodynamics of multiple oral doses of apixaban, a factor Xa inhibitor, in healthy subjects

AIM: Apixaban is an oral factor Xa inhibitor approved for stroke prevention in atrial fibrillation and thromboprophylaxis in patients who have undergone elective hip or knee replacement surgery and under development for treatment of venous thromboembolism. This study examined the safety, pharmacokin...

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Detalhes bibliográficos
Main Authors: Frost, Charles, Nepal, Sunil, Wang, Jessie, Schuster, Alan, Byon, Wonkyung, Boyd, Rebecca A, Yu, Zhigang, Shenker, Andrew, Barrett, Yu Chen, Mosqueda-Garcia, Rogelio, LaCreta, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Pharmacokinetic Dynamic Relationships
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853536/
https://ncbi.nlm.nih.gov/pubmed/23451769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12106
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