Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor

AIM: Apixaban is an orally active inhibitor of coagulation factor Xa and is eliminated by multiple pathways, including renal and non-renal elimination. Non-renal elimination pathways consist of metabolism by cytochrome P450 (CYP) enzymes, primarily CYP3A4, as well as direct intestinal excretion. Two...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Frost, Charles E, Byon, Wonkyung, Song, Yan, Wang, Jessie, Schuster, Alan E, Boyd, Rebecca A, Zhang, Donglu, Yu, Zhigang, Dias, Clapton, Shenker, Andrew, LaCreta, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415720/
https://ncbi.nlm.nih.gov/pubmed/25377242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12541
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