Evaluation of the effect of naproxen on the pharmacokinetics and pharmacodynamics of apixaban

AIM: To assess pharmacokinetic and pharmacodynamic interactions between naproxen (a non-steroidal anti-inflammatory drug) and apixaban (an oral, selective, direct factor-Xa inhibitor). METHOD: In this randomized, three period, two sequence study, 21 healthy subjects received a single oral dose of ap...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Frost, Charles, Shenker, Andrew, Gandhi, Mohit D, Pursley, Janice, Barrett, Yu Chen, Wang, Jessie, Zhang, Donglu, Byon, Wonkyung, Boyd, Rebecca A, LaCreta, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239981/
https://ncbi.nlm.nih.gov/pubmed/24697979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12393
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