Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects

AIM: Apixaban is an oral, direct, factor-Xa inhibitor approved for thromboprophylaxis in patients who have undergone elective hip or knee replacement surgery and for prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation. This open label, parallel group study in...

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Main Authors: Upreti, Vijay V, Wang, Jessie, Barrett, Yu Chen, Byon, Wonkyung, Boyd, Rebecca A, Pursley, Janice, LaCreta, Frank P, Frost, Charles E
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2013
Teme:
Pharmacokinetic Dynamic Relationships
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845314/
https://ncbi.nlm.nih.gov/pubmed/23488672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12114
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