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Inactivation of Uaf1 Causes Defective Homologous Recombination and Early Embryonic Lethality in Mice
The deubiquitinating enzyme heterodimeric complex USP1-UAF1 regulates the Fanconi anemia (FA) DNA repair pathway. Absence of this complex leads to increased cellular levels of ubiquitinated FANCD2 (FANCD2-Ub) and ubiquitinated PCNA (PCNA-Ub). Mice deficient in the catalytic subunit of the complex, U...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3838189/ https://ncbi.nlm.nih.gov/pubmed/24001775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00870-13 |
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