Inactivation of Uaf1 Causes Defective Homologous Recombination and Early Embryonic Lethality in Mice

The deubiquitinating enzyme heterodimeric complex USP1-UAF1 regulates the Fanconi anemia (FA) DNA repair pathway. Absence of this complex leads to increased cellular levels of ubiquitinated FANCD2 (FANCD2-Ub) and ubiquitinated PCNA (PCNA-Ub). Mice deficient in the catalytic subunit of the complex, U...

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Detaylı Bibliyografya
Asıl Yazarlar: Park, Eunmi, Kim, Jung Min, Primack, Benjamin, Weinstock, David M., Moreau, Lisa A., Parmar, Kalindi, D'Andrea, Alan D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2013
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838189/
https://ncbi.nlm.nih.gov/pubmed/24001775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00870-13
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