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Inactivation of the Sema5a Gene Results in Embryonic Lethality and Defective Remodeling of the Cranial Vascular System

The semaphorins are a large family of proteins involved in the patterning of both the vascular and the nervous systems. In order to analyze the function of the membrane-bound semaphorin 5A (Sema5A), we generated mice homozygous for a null mutation in the Sema5a gene. Homozygous null mutants die betw...

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Main Authors: Fiore, Roberto, Rahim, Belquis, Christoffels, Vincent M., Moorman, Antoon F. M., Püschel, Andreas W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061610/
https://ncbi.nlm.nih.gov/pubmed/15743826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.6.2310-2319.2005
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