Complete Loss of Ndel1 Results in Neuronal Migration Defects and Early Embryonic Lethality

Regulation of cytoplasmic dynein and microtubule dynamics is crucial for both mitotic cell division and neuronal migration. NDEL1 was identified as a protein interacting with LIS1, the protein product of a gene mutated in the lissencephaly. To elucidate NDEL1 function in vivo, we generated null and...

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Autores principales: Sasaki, Shinji, Mori, Daisuke, Toyo-oka, Kazuhito, Chen, Amy, Garrett-Beal, Lisa, Muramatsu, Masami, Miyagawa, Shuji, Hiraiwa, Noriko, Yoshiki, Atsushi, Wynshaw-Boris, Anthony, Hirotsune, Shinji
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190282/
https://ncbi.nlm.nih.gov/pubmed/16107726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.17.7812-7827.2005
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