Inactivation of CtIP Leads to Early Embryonic Lethality Mediated by G(1) Restraint and to Tumorigenesis by Haploid Insufficiency

CtIP interacts with a group of tumor suppressor proteins including RB (retinoblastoma protein), BRCA1, Ikaros, and CtBP, which regulate cell cycle progression through transcriptional repression as well as chromatin remodeling. However, how CtIP exerts its biological function in cell cycle progressio...

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Detalhes bibliográficos
Main Authors: Chen, Phang-Lang, Liu, Feng, Cai, Suna, Lin, Xiaoqin, Li, Aihua, Chen, Yumay, Gu, Bingnan, Lee, Eva Y.-H. P., Lee, Wen-Hwa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084307/
https://ncbi.nlm.nih.gov/pubmed/15831459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.9.3535-3542.2005
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