Inactivation of CtIP Leads to Early Embryonic Lethality Mediated by G(1) Restraint and to Tumorigenesis by Haploid Insufficiency

CtIP interacts with a group of tumor suppressor proteins including RB (retinoblastoma protein), BRCA1, Ikaros, and CtBP, which regulate cell cycle progression through transcriptional repression as well as chromatin remodeling. However, how CtIP exerts its biological function in cell cycle progressio...

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Bibliografiske detaljer
Main Authors: Chen, Phang-Lang, Liu, Feng, Cai, Suna, Lin, Xiaoqin, Li, Aihua, Chen, Yumay, Gu, Bingnan, Lee, Eva Y.-H. P., Lee, Wen-Hwa
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084307/
https://ncbi.nlm.nih.gov/pubmed/15831459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.9.3535-3542.2005
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