Common PIK3CA Mutants and a Novel 3′ UTR Mutation Are Associated with Increased Sensitivity to Saracatinib

PURPOSE: Dysregulation of the phosphoinositide 3-kinase (PI3K) and Src signaling pathways commonly occur in colorectal cancer. Mutations in the PIK3CA gene are associated with an increase in severity of disease and worse clinical outcomes. Elevated levels of Src have been identified in premalignant...

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Autors principals: Arcaroli, John J., Quackenbush, Kevin S., Powell, Rebecca W., Pitts, Todd M., Spreafico, Anna, Varella-Garcia, Marileila, Bemis, Lynne, Tan, Aik Choon, Reinemann, Jaclyn M., Touban, Basel M., Dasari, Arvind, Eckhardt, S. Gail, Messersmith, Wells A.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836589/
https://ncbi.nlm.nih.gov/pubmed/22553375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-3167
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