LRRK2 secretion in exosomes is regulated by 14-3-3

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset Parkinson's disease (PD). Emerging evidence suggests a role for LRRK2 in the endocytic pathway. Here, we show that LRRK2 is released in extracellular microvesicles (i.e. exosomes) from cells that natively express LRRK2....

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Main Authors: Fraser, Kyle B., Moehle, Mark S., Daher, João P.L., Webber, Philip J., Williams, Jeri Y., Stewart, Carrie A., Yacoubian, Talene A., Cowell, Rita M., Dokland, Terje, Ye, Tong, Chen, Dongquan, Siegal, Gene P., Galemmo, Robert A., Tsika, Elpida, Moore, Darren J., Standaert, David G., Kojima, Kyoko, Mobley, James A., West, Andrew B.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836478/
https://ncbi.nlm.nih.gov/pubmed/23886663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt346
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