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Contribution of GTPase activity to LRRK2-associated Parkinson disease
Mutations in the leucine-rich repeat kinase 2 (LRRK2, PARK8, OMIM 607060) gene represent the most common known cause of hereditary Parkinson’s disease (PD) with late-onset and dominant inheritance. LRRK2 protein is composed of multiple domains including two distinct enzymatic domains, a kinase and a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3976973/ https://ncbi.nlm.nih.gov/pubmed/24025585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.25130 |
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